DICER1-related cancers

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Mutations in the microRNA-processing gene DICER1 predispose individuals to a spectrum of rare pediatric cancers.

We use a combination of genomic analysis, cell-based models, and in vivo systems to understand how DICER1 dysfunction alters gene expression and drives tumorigenesis, in terms of:

• Mechanisms of microRNA loss
• Tumor-specific vulnerabilities
• Translational opportunities