Here are some of our latest works.
Desai K, Tiburcio PDB, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Chen KS. PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor. bioRxiv [Preprint]. doi:10.1101/2024.11.29.626084
Tiburcio PDB, Chen K, Xu L, Chen KS. Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor. bioRxiv [Preprint]. doi:10.1101/2024.06.11.598518
Fraire CR, Desai K, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Chen KS. An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma. bioRxiv [Preprint]. doi:10.1101/2024.04.23.590638v3
Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KAP. Anaplastic Sarcoma of the Kidney (DICER1-Sarcoma of the Kidney): A Report from the International Pleuropulmonary Blastoma/ DICER1 Registry. Pediatr Blood Cancer. 2024; e31090. doi:10.1002/pbc.31090 | PubMed
Tiburcio PDB, Desai K, Kim J, Zhou Q, Guo L, Xiao X, Zhou L, Yuksel A, Catchpoole DR, Amatruda JF, Xu L, Chen KS. DROSHA regulates mesenchymal gene expression in Wilms tumor. Mol Cancer Res. 2024 Apr 22. doi:10.1158/1541-7786.MCR-23-0930 | PubMed
Fraire CR, Mallinger PR, Hatton JN, Kim J, Dickens DS, Argenta PA, Milanovich S, Hartshorne T, Carey DJ, Haley JS, Urban G, Lee J, Hill DA, Stewart DR, Schultz KAP, Chen KS. Intronic germline DICER1 variants in patients with Sertoli-Leydig cell tumor. JCO Precis Oncol. 2023; 7: e2300189. doi:10.1200/PO.23.00189 | PubMed | PMC
Aguayo JS, Shelton JM, Tan W, Rakheja D, Cai C, Shalaby A, Lee J, Iannaccone ST, Xu L, Chen KS, Burns DK, Zheng Y. Ectopic PLAG1 induces muscular dystrophy in the mouse. Biochem Biophys Res Commun. 2023 Jul 12;665:159-168. doi:10.1016/j.bbrc.2023.05.006 | PubMed